CURRENT:
Appendix 6
| Types of Insulin | |||
| Insulin type (trade name) | Onset | Peak | Duration |
| Bolus (preprandial or mealtime) insulins | |||
Rapid-acting insulin analogues (clear)
| 9-20min 10-15min 10-15min 4min | 1-1.5h 1-1.5h 1-2h 0.5-1.5h | 3-5h 3.5-5h 3-4.75h 3-5h |
Short-acting insulins (clear)
| 30min 15min | 2-3h 4-8h | 6.5h 17-24h |
| Basal insulins | |||
Intermediate-acting (cloudy)
| 1-3h | 5-8h | Up to 18h |
Long-acting insulin (clear)
| 90min | Not applicable | U-100 glardine 24h, detemir 16-24h U-300 glargine >30h degludec 42h |
| Premixed insulins | |||
Premixed regular insulin –NPH (cloudy)
| A single vial or cartridge contains a fixed ratio of insulin | ||
Premixed insulin analogues (cloudy)
| (% of rapid-acting or short-acting insulin to % of intermediate-acting insulin) | ||
Data represents estimations derived from pooled data analysis using various experimental conditions. There is significant inter- and intra-individual variation in pharmacokinetics and pharmacodynamics depending on a variety of clinical factors, including dose. Physicians should refer to the most current edition of Compendium of Pharmaceuticals and Specialties (Canadian Pharmacists Association; Ottawa, Ontario, Canada) and products monographs for detailed information. | |||